Application of a Physiologically Based Pharmacokinetic Model to Characterize Time-dependent Metabolism of Voriconazole in Children and Support Dose Optimization

Background: Voriconazole is a potent antifungal drug with complex pharmacokinetics caused by time-dependent inhibition and polymorphisms of metabolizing enzymes. It also exhibits different pharmacokinetic characteristics between adults and children. An understanding of these alterations in pharmacok...

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Main Authors: Yahui Zhang (Author), Sixuan Zhao (Author), Chuhui Wang (Author), Pengxiang Zhou (Author), Suodi Zhai (Author)
Format: Book
Published: Frontiers Media S.A., 2021-03-01T00:00:00Z.
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