ERα-Targeting PROTAC as a Chemical Knockdown Tool to Investigate the Estrogen Receptor Function in Rat Menopausal Arthritis

• Hoofdauteurs: Li Duan (Auteur), Xiao Xu (Auteur), Limei Xu (Auteur), Caining Wen (Auteur), Kan Ouyang (Auteur), Zigang Li (Auteur), Yujie Liang (Auteur)
• Formaat: Boek
• Gepubliceerd in: Frontiers Media S.A., 2021-11-01T00:00:00Z.
• Onderwerpen: article
• Online toegang: Connect to this object online.

Proteolytic targeting chimeras (PROTACs) is a rapid and reversible chemical knockout method. Compared with traditional gene-editing tools, it can avoid potential genetic compensation, misunderstandings caused by spontaneous mutations, or gene knockouts that lead to embryonic death. To study the role...