Consideration of Metabolite Efflux in Radiolabelled Choline Kinetics

• Main Authors: Yunqing Li (Author), Marianna Inglese (Author), Suraiya Dubash (Author), Chris Barnes (Author), Diana Brickute (Author), Marta Costa Braga (Author), Ning Wang (Author), Alice Beckley (Author), Kathrin Heinzmann (Author), Louis Allott (Author), Haonan Lu (Author), Cen Chen (Author), Ruisi Fu (Author), Laurence Carroll (Author), Eric O. Aboagye (Author)
• Format: Book
• Published: MDPI AG, 2021-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Hypoxia is a complex microenvironmental condition known to regulate choline kinase α (CHKA) activity and choline transport through transcription factor hypoxia-inducible factor-1α (HIF-1α) and, therefore, may confound the uptake of choline radiotracer [¹⁸F]fluoromethyl-[1,2-&l...