A PDE10A inhibitor CPL500036 is a novel agent modulating striatal function devoid of most neuroleptic side-effects
Background: Phosphodiesterase 10A (PDE10A) is expressed almost exclusively in the striatum and its inhibition is suggested to offer potential treatment in disorders associated with basal ganglia. We evaluated the selectivity, cytotoxicity, genotoxicity, pharmacokinetics and potential adverse effects...
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Main Authors: | , , , , , , , , , , , , , , , , , , |
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Format: | Book |
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Frontiers Media S.A.,
2022-11-01T00:00:00Z.
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A1234.567 |
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Copy 1 | Available |