p21 induces a senescence program and skeletal muscle dysfunction

• Autori principali: Davis A. Englund (Autore), Alyssa Jolliffe (Autore), Zaira Aversa (Autore), Xu Zhang (Autore), Ines Sturmlechner (Autore), Ayumi E. Sakamoto (Autore), Julianna D. Zeidler (Autore), Gina M. Warner (Autore), Colton McNinch (Autore), Thomas A. White (Autore), Eduardo N. Chini (Autore), Darren J. Baker (Autore), Jan M. van Deursen (Autore), Nathan K. LeBrasseur (Autore)
• Natura: Libro
• Pubblicazione: Elsevier, 2023-01-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

Recent work has established associations between elevated p21, the accumulation of senescent cells, and skeletal muscle dysfunction in mice and humans. Using a mouse model of p21 overexpression (p21OE), we examined if p21 mechanistically contributes to cellular senescence and pathological features i...