Daily consumption of ketone ester, bis-octanoyl (R)-1,3-butanediol, is safe and tolerable in healthy older adults in a randomized, parallel arm, double-blind, placebo-controlled, pilot study

• Main Authors: Brianna J. Stubbs (Author), Elizabeth B. Stephens (Author), Chatura Senadheera (Author), Sawyer Peralta (Author), Stephanie Roa-Diaz (Author), Laura Alexander (Author), Wendie Silverman-Martin (Author), Thelma Y. Garcia (Author), Michi Yukawa (Author), Jenifer Morris (Author), Traci M. Blonquist (Author), James B. Johnson (Author), John C. Newman (Author)
• Format: Book
• Published: Elsevier, 2024-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objectives: Ketone bodies are endogenous metabolites produced during fasting or a ketogenic diet that have pleiotropic effects on aging pathways. Ketone esters (KEs) are compounds that induce ketosis without dietary changes, but KEs have not been studied in an older adult population. The primary obj...