Macrophage Infiltration Initiates RIP3/MLKL-Dependent Necroptosis in Paclitaxel-Induced Neuropathic Pain

• Main Authors: Dongyang Ma (Author), Xiuli Wang (Author), Xin Liu (Author), Zhao Li (Author), Jiaxin Liu (Author), Jing Cao (Author), Guiying Wang (Author), Yuexian Guo (Author), Shuang Zhao (Author)
• Format: Book
• Published: Hindawi Limited, 2022-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Paclitaxel (PTX) is a commonly used antitumor drug. Approximately 80% of all patients receiving PTX chemotherapy develop chemotherapy-induced peripheral neuropathy (CIPN), limiting the use of PTX. Moreover, CIPN responds poorly to conventional analgesics. Experimental evidence suggests that the neur...