Retroposed copies of RET gene: a somatically acquired event in medullary thyroid carcinoma

• Main Authors: Larissa V. Bim (Author), Fábio C. P. Navarro (Author), Flávia O. F. Valente (Author), José V. Lima-Junior (Author), Rosana Delcelo (Author), Magnus R. Dias- (Author), Rui M. B. Maciel (Author), Pedro A. F. Galante (Author), Janete M. Cerutti (Author)
• Format: Book
• Published: BMC, 2019-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Different pathogenic germline mutations in the RET oncogene are identified in MEN 2, a hereditary syndrome characterized by medullary thyroid carcinoma (MTC) and other endocrine tumors. Although genetic predisposition is recognized, not all RET mutation carriers will develop the...