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Metabolomic Profile and Antioxidant/Anti-Inflammatory Effects of Industrial Hemp Water Extract in Fibroblasts, Keratinocytes and Isolated Mouse Skin Specimens

Industrial hemp is a multiuse crop whose phytocomplex includes terpenophenolics and flavonoids. In the present study, the phenolic and terpenophenolic compounds were assayed in the water extract of the hemp variety Futura 75. Protective effects were also investigated in human fibroblast and keratino...

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Մատենագիտական մանրամասներ
Հիմնական հեղինակներ: Viviana di Giacomo (Հեղինակ), Lucia Recinella (Հեղինակ), Annalisa Chiavaroli (Հեղինակ), Giustino Orlando (Հեղինակ), Amelia Cataldi (Հեղինակ), Monica Rapino (Հեղինակ), Valentina Di Valerio (Հեղինակ), Matteo Politi (Հեղինակ), Marco Daniel Antolini (Հեղինակ), Alessandra Acquaviva (Հեղինակ), Francesco Bacchin (Հեղինակ), Massimo Di Mascio (Հեղինակ), Sheila Leone (Հեղինակ), Luigi Brunetti (Հեղինակ), Luigi Menghini (Հեղինակ), Simone Carradori (Հեղինակ), Gokhan Zengin (Հեղինակ), Gunes Ak (Հեղինակ), Claudio Ferrante (Հեղինակ)
Ձևաչափ: Գիրք
Հրապարակվել է: MDPI AG, 2021-01-01T00:00:00Z.
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Նկարագրություն
Ամփոփում:Industrial hemp is a multiuse crop whose phytocomplex includes terpenophenolics and flavonoids. In the present study, the phenolic and terpenophenolic compounds were assayed in the water extract of the hemp variety Futura 75. Protective effects were also investigated in human fibroblast and keratinocytes and isolate mouse skin specimens, which were exposed to hydrogen peroxide and/or to the extract (1-500 µg/mL). The results of phytochemical analysis suggested the cannabidiol, cannabidiolic acid and rutin as the prominent phytocompounds. In the in vitro system represented by human keratinocytes and fibroblasts, the hemp extract was found to be able to protect cells from cytotoxicity and apoptosis induced by oxidative stress. Moreover, modulatory effects on IL-6, a key mediator in skin proliferation, were found. In isolated rat skin, the extract reduced hydrogen peroxide-induced l-dopa turnover, prostaglandin-E2 production and the ratio kynurenine/tryptpophan, thus corroborating anti-inflammatory/antioxidant effects. The in silico docking studies also highlighted the putative interactions between cannabidiol, cannabidiolic acid and rutin with tyrosinase and indoleamine-2,3-dioxygenase, involved in l-dopa turnover and tryptophan conversion in kynurenine, respectively. In conclusion, the present findings showed the efficacy of hemp water extract as a skin protective agent. This could be partly related to the extract content in cannabidiol, cannabidiolic acid and rutin.
Նյութի նկարագրություն:10.3390/antiox10010044
2076-3921

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