siRNA-Encapsulated Hybrid Nanoparticles Target Mutant K-ras and Inhibit Metastatic Tumor Burden in a Mouse Model of Lung Cancer

• Main Authors: Maryna Perepelyuk (Author), Olubunmi Shoyele (Author), Ruth Birbe (Author), Chellappagounder Thangavel (Author), Yi Liu (Author), Robert B. Den (Author), Adam E. Snook (Author), Bo Lu (Author), Sunday A. Shoyele (Author)
• Format: Book
• Published: Elsevier, 2017-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

There is an unmet need in the development of an effective therapy for mutant K-ras-expressing non-small-cell lung cancer (NSCLC). Although various small molecules have been evaluated, an effective therapy remains a dream. siRNAs have the potential to downregulate mutant K-ras both at the protein and...