Therapeutic Drug Monitoring of Tacrolimus-Personalized Therapy in Heart Transplantation: New Strategies and Preliminary Results in Endomyocardial Biopsies

• Main Authors: Simona De Gregori (Author), Annalisa De Silvestri (Author), Barbara Cattadori (Author), Andrea Rapagnani (Author), Riccardo Albertini (Author), Elisa Novello (Author), Monica Concardi (Author), Eloisa Arbustini (Author), Carlo Pellegrini (Author)
• Format: Book
• Published: MDPI AG, 2022-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Tacrolimus (TAC) is an immunosuppressant drug approved both in the US and in the EU, widely used for the prophylaxis of organ rejection after transplantation. This is a critical dose drug: low levels in whole blood can lead to low exposure and a high risk of acute rejection, whereas overexposure put...