QSAR and Chemical Read-Across Analysis of 370 Potential MGMT Inactivators to Identify the Structural Features Influencing Inactivation Potency

• Main Authors: Guohui Sun (Author), Peiying Bai (Author), Tengjiao Fan (Author), Lijiao Zhao (Author), Rugang Zhong (Author), R. Stanley McElhinney (Author), T. Brian H. McMurry (Author), Dorothy J. Donnelly (Author), Joan E. McCormick (Author), Jane Kelly (Author), Geoffrey P. Margison (Author)
• Format: Book
• Published: MDPI AG, 2023-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

<i>O</i>⁶-methylguanine-DNA methyltransferase (MGMT) constitutes an important cellular mechanism for repairing potentially cytotoxic DNA damage induced by guanine <i>O</i>⁶-alkylating agents and can render cells highly resistant t...