LncRNA GAS5 suppresses TGF-β1-induced transformation of pulmonary pericytes into myofibroblasts by recruiting KDM5B and promoting H3K4me2/3 demethylation of the PDGFRα/β promoter

• Main Authors: Yichun Wang (Author), Diyu Chen (Author), Han Xie (Author), Shuhua Zhou (Author), Mingwang Jia (Author), Xiaobo He (Author), Feifei Guo (Author), Yihuan Lai (Author), Xiao Xiao Tang (Author)
• Format: Book
• Published: BMC, 2023-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Idiopathic pulmonary fibrosis (IPF) is a condition that may cause persistent pulmonary damage. The transformation of pericytes into myofibroblasts has been recognized as a key player during IPF progression. This study aimed to investigate the functions of lncRNA growth arrest-spe...