Toxicokinetics of β-Amanitin in Mice and In Vitro Drug-Drug Interaction Potential

• Main Authors: Young Yoon Bang (Author), Im-Sook Song (Author), Min Seo Lee (Author), Chang Ho Lim (Author), Yong-Yeon Cho (Author), Joo Young Lee (Author), Han Chang Kang (Author), Hye Suk Lee (Author)
• Format: Book
• Published: MDPI AG, 2022-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The toxicokinetics of β-amanitin, a toxic bicyclic octapeptide present abundantly in Amanitaceae mushrooms, was evaluated in mice after intravenous (iv) and oral administration. The area under plasma concentration curves (AUC) following iv injection increased in proportion to doses of 0.2, 0.4, and...