Interaction of γ-Polyglutamic Acid/Polyethyleneimine/Plasmid DNA Ternary Complexes with Serum Components Plays a Crucial Role in Transfection in Mice

• Główni autorzy: Tomotaka Ko (Autor), Shintaro Fumoto (Autor), Tomoaki Kurosaki (Autor), Moe Nakashima (Autor), Hirotaka Miyamoto (Autor), Hitoshi Sasaki (Autor), Koyo Nishida (Autor)
• Format: Książka
• Wydane: MDPI AG, 2024-04-01T00:00:00Z.
• Hasła przedmiotowe: article
• Dostęp online: Connect to this object online.

Typical examples of non-viral vectors are binary complexes of plasmid DNA with cationic polymers such as polyethyleneimine (PEI). However, problems such as cytotoxicity and hemagglutination, owing to their positively charged surfaces, hinder their in vivo use. Coating binary complexes with anionic p...