Tofacitinib Loaded Squalenyl Nanoparticles for Targeted Follicular Delivery in Inflammatory Skin Diseases

• Main Authors: Rebekka Christmann (Author), Duy-Khiet Ho (Author), Jenny Wilzopolski (Author), Sangeun Lee (Author), Marcus Koch (Author), Brigitta Loretz (Author), Thomas Vogt (Author), Wolfgang Bäumer (Author), Ulrich F. Schaefer (Author), Claus-Michael Lehr (Author)
• Format: Book
• Published: MDPI AG, 2020-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Tofacitinib (TFB), a Janus kinase inhibitor, has shown excellent success off-label in treating various dermatological diseases, especially alopecia areata (AA). However, TFB's safe and targeted delivery into hair follicles (HFs) is highly desirable due to its systemic adverse effects. Nanoparti...