Activation of PI3K/AKT/mTOR signaling axis by UBE2S inhibits autophagy leading to cisplatin resistance in ovarian cancer

• Main Authors: Mengjun Zhang (Author), Jialin Wang (Author), Yan Guo (Author), Haodi Yue (Author), Lindong Zhang (Author)
• Formato: Libro
• Publicado: BMC, 2023-12-01T00:00:00Z.
• Subjects: article
• Acceso en liña: Connect to this object online.

Abstract Background Epithelial ovarian cancer (OC) is the fourth leading cause of cancer-related deaths in women, with a 5-year survival rate of 30%-50%. Platinum resistance is the chief culprit for the high recurrence and mortality rates. Several studies confirm that the metabolic regulation of ubi...