Design, synthesis, and evaluation of 3,7-substituted coumarin derivatives as multifunctional Alzheimer's disease agents

• Hauptverfasser: Sheunopa C. Mzezewa (Verfasst von), Sylvester I. Omoruyi (Verfasst von), Luke S. Zondagh (Verfasst von), Sarel F. Malan (Verfasst von), Okobi E. Ekpo (Verfasst von), Jacques Joubert (Verfasst von)
• Format: Buch
• Veröffentlicht: Taylor & Francis Group, 2021-01-01T00:00:00Z.
• Schlagworte: article
• Online-Zugang: Connect to this object online.

Multitarget directed ligands (MTDLs) are emerging as promising treatment options for Alzheimer's disease (AD). Coumarin derivatives serve as a good starting point for designing MTDLs due to their inherent inhibition of monoamine oxidase (MAO) and cholinesterase enzymes, which are complicit in A...