Design, synthesis, and evaluation of 3,7-substituted coumarin derivatives as multifunctional Alzheimer's disease agents

• Главные авторы: Sheunopa C. Mzezewa (Автор), Sylvester I. Omoruyi (Автор), Luke S. Zondagh (Автор), Sarel F. Malan (Автор), Okobi E. Ekpo (Автор), Jacques Joubert (Автор)
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• Опубликовано: Taylor & Francis Group, 2021-01-01T00:00:00Z.
• Предметы: article
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Multitarget directed ligands (MTDLs) are emerging as promising treatment options for Alzheimer's disease (AD). Coumarin derivatives serve as a good starting point for designing MTDLs due to their inherent inhibition of monoamine oxidase (MAO) and cholinesterase enzymes, which are complicit in A...