Acid sphingomyelinase deficiency in Western diet-fed mice protects against adipocyte hypertrophy and diet-induced liver steatosis

• Main Authors: Svenja Sydor (Author), Jan-Peter Sowa (Author), Dominik A. Megger (Author), Martin Schlattjan (Author), Sami Jafoui (Author), Lena Wingerter (Author), Alexander Carpinteiro (Author), Hideo A. Baba (Author), Lars P. Bechmann (Author), Barbara Sitek (Author), Guido Gerken (Author), Erich Gulbins (Author), Ali Canbay (Author)
• Formato: Livro
• Publicado em: Elsevier, 2017-05-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

Objective: Alterations in sphingolipid and ceramide metabolism have been associated with various diseases, including nonalcoholic fatty liver disease (NAFLD). Acid sphingomyelinase (ASM) converts the membrane lipid sphingomyelin to ceramide, thereby affecting membrane composition and domain formatio...