Acid sphingomyelinase deficiency in Western diet-fed mice protects against adipocyte hypertrophy and diet-induced liver steatosis

• मुख्य लेखकों: Svenja Sydor (लेखक), Jan-Peter Sowa (लेखक), Dominik A. Megger (लेखक), Martin Schlattjan (लेखक), Sami Jafoui (लेखक), Lena Wingerter (लेखक), Alexander Carpinteiro (लेखक), Hideo A. Baba (लेखक), Lars P. Bechmann (लेखक), Barbara Sitek (लेखक), Guido Gerken (लेखक), Erich Gulbins (लेखक), Ali Canbay (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Elsevier, 2017-05-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Objective: Alterations in sphingolipid and ceramide metabolism have been associated with various diseases, including nonalcoholic fatty liver disease (NAFLD). Acid sphingomyelinase (ASM) converts the membrane lipid sphingomyelin to ceramide, thereby affecting membrane composition and domain formatio...