Prevalence of the co-prescription of tamoxifen and CYP2D6 inhibitors in Saudi population: A cross sectional study

• Main Authors: Azher Arafah (Author), Khalid Yakout (Author), Muneeb U. Rehman (Author), Ammar Mohammed Alsharif (Author), Mohammad H. AlJawadi (Author), Hussain Abdulrahman Al-Omar (Author)
• Format: Book
• Published: Elsevier, 2020-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Consumption of Cytochrome P450 2D6 (CYP2D6) inhibiting drugs along with tamoxifen treatment results in decrease in plasma concentration of endoxifen, the major active tamoxifen metabolite. Simultaneous use of CYP2D6 inhibitors, such as selective serotonin reuptake inhibitors (SSIs), as well as lesse...