Placental mesenchymal stem cells ameliorate NLRP3 inflammasome-induced ovarian insufficiency by modulating macrophage M2 polarization

• Main Authors: Dongmei Chen (Author), Na Hu (Author), Shasha Xing (Author), Li Yang (Author), Feiyan Zhang (Author), Songlin Guo (Author), Shudan Liu (Author), Xiaona Ma (Author), Xueyun Liang (Author), Huiming Ma (Author)
• Format: Book
• Published: BMC, 2023-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Premature ovarian insufficiency (POI) is a common clinical problem, however, there are currently no effective therapies. Pyroptosis induced by the NLRP3 inflammasome is considered a possible mechanism of POI. Placental mesenchymal stem cells (PMSCs) have excellent immunomodulator...