Hydrophobic Optimization of Functional Poly(TPAE-co-suberoyl chloride) for Extrahepatic mRNA Delivery following Intravenous Administration

• Main Authors: Xueliang Yu (Author), Shuai Liu (Author), Qiang Cheng (Author), Sang M. Lee (Author), Tuo Wei (Author), Di Zhang (Author), Lukas Farbiak (Author), Lindsay T. Johnson (Author), Xu Wang (Author), Daniel John Siegwart (Author)
• Format: Book
• Published: MDPI AG, 2021-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Messenger RNA (mRNA) has generated great attention due to its broad potential therapeutic applications, including vaccines, protein replacement therapy, and immunotherapy. Compared to other nucleic acids (e.g., siRNA and pDNA), there are more opportunities to improve the delivery efficacy of mRNA th...