First-in-human study to investigate the safety and pharmacokinetics of salvianolic acid A and pharmacokinetic simulation using a physiologically based pharmacokinetic model

• Hauptverfasser: Jinliang Chen (Verfasst von), Zourong Ruan (Verfasst von), Honggang Lou (Verfasst von), Dandan Yang (Verfasst von), Rong Shao (Verfasst von), Yichao Xu (Verfasst von), Xinhua Hu (Verfasst von), Bo Jiang (Verfasst von)
• Format: Buch
• Veröffentlicht: Frontiers Media S.A., 2022-11-01T00:00:00Z.
• Schlagworte: article
• Online-Zugang: Connect to this object online.

Salvianolic acid A (SAA) is a water-soluble phenolic acid component from Salvia miltiorrhiza Bunge currently under development for myocardial protection treatment for coronary heart disease (CHD). We investigated the safety, tolerability, and pharmacokinetics of single and multiple ascending doses o...