Protein Expression Knockdown in Cancer Cells Induced by a Gemini Cationic Lipid Nanovector with Histidine-Based Polar Heads

• Main Authors: Natalia Sánchez-Arribas (Author), María Martínez-Negro (Author), Eva M. Villar (Author), Lourdes Pérez (Author), José Osío Barcina (Author), Emilio Aicart (Author), Pablo Taboada (Author), Andrés Guerrero-Martínez (Author), Elena Junquera (Author)
• Format: Book
• Published: MDPI AG, 2020-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

A histidine-based gemini cationic lipid, which had already demonstrated its efficiency as a plasmid DNA (pDNA) nanocarrier, has been used in this work to transfect a small interfering RNA (siRNA) into cancer cells. In combination with the helper lipid monoolein glycerol (MOG), the cationic lipid was...