Reduced variability in tacrolimus pharmacokinetics following intramuscular injection compared to oral administration in cynomolgus monkeys: Investigating optimal dosing regimens

• Main Authors: Kyo Won Lee (Author), Tae Hwan Kim (Author), Jong Bong Lee (Author), Kyeong Sik Kim (Author), Jae Berm Park (Author), Pavel Gershkovich (Author), Sun Dong Yoo (Author), Soyoung Shin (Author), Beom Soo Shin (Author), Sung Joo Kim (Author)
• Format: Book
• Published: Elsevier, 2019-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Tacrolimus is one of the most commonly used immunosuppressive agents in animal models of transplantation. However, in these models, oral administration is often problematic due to the lowered compliance associated with highly invasive surgery and due to malabsorption in the intestinal tract. Therefo...