Reduced variability in tacrolimus pharmacokinetics following intramuscular injection compared to oral administration in cynomolgus monkeys: Investigating optimal dosing regimens

• المؤلفون الرئيسيون: Kyo Won Lee (مؤلف), Tae Hwan Kim (مؤلف), Jong Bong Lee (مؤلف), Kyeong Sik Kim (مؤلف), Jae Berm Park (مؤلف), Pavel Gershkovich (مؤلف), Sun Dong Yoo (مؤلف), Soyoung Shin (مؤلف), Beom Soo Shin (مؤلف), Sung Joo Kim (مؤلف)
• التنسيق: كتاب
• منشور في: Elsevier, 2019-02-01T00:00:00Z.
• الموضوعات: article
• الوصول للمادة أونلاين: Connect to this object online.

Tacrolimus is one of the most commonly used immunosuppressive agents in animal models of transplantation. However, in these models, oral administration is often problematic due to the lowered compliance associated with highly invasive surgery and due to malabsorption in the intestinal tract. Therefo...