Reduced variability in tacrolimus pharmacokinetics following intramuscular injection compared to oral administration in cynomolgus monkeys: Investigating optimal dosing regimens

• Hauptverfasser: Kyo Won Lee (Verfasst von), Tae Hwan Kim (Verfasst von), Jong Bong Lee (Verfasst von), Kyeong Sik Kim (Verfasst von), Jae Berm Park (Verfasst von), Pavel Gershkovich (Verfasst von), Sun Dong Yoo (Verfasst von), Soyoung Shin (Verfasst von), Beom Soo Shin (Verfasst von), Sung Joo Kim (Verfasst von)
• Format: Buch
• Veröffentlicht: Elsevier, 2019-02-01T00:00:00Z.
• Schlagworte: article
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Tacrolimus is one of the most commonly used immunosuppressive agents in animal models of transplantation. However, in these models, oral administration is often problematic due to the lowered compliance associated with highly invasive surgery and due to malabsorption in the intestinal tract. Therefo...