Reduced variability in tacrolimus pharmacokinetics following intramuscular injection compared to oral administration in cynomolgus monkeys: Investigating optimal dosing regimens

• Κύριοι συγγραφείς: Kyo Won Lee (Συγγραφέας), Tae Hwan Kim (Συγγραφέας), Jong Bong Lee (Συγγραφέας), Kyeong Sik Kim (Συγγραφέας), Jae Berm Park (Συγγραφέας), Pavel Gershkovich (Συγγραφέας), Sun Dong Yoo (Συγγραφέας), Soyoung Shin (Συγγραφέας), Beom Soo Shin (Συγγραφέας), Sung Joo Kim (Συγγραφέας)
• Μορφή: Βιβλίο
• Έκδοση: Elsevier, 2019-02-01T00:00:00Z.
• Θέματα: article
• Διαθέσιμο Online: Connect to this object online.

Tacrolimus is one of the most commonly used immunosuppressive agents in animal models of transplantation. However, in these models, oral administration is often problematic due to the lowered compliance associated with highly invasive surgery and due to malabsorption in the intestinal tract. Therefo...