Reduced variability in tacrolimus pharmacokinetics following intramuscular injection compared to oral administration in cynomolgus monkeys: Investigating optimal dosing regimens

• Những tác giả chính: Kyo Won Lee (Tác giả), Tae Hwan Kim (Tác giả), Jong Bong Lee (Tác giả), Kyeong Sik Kim (Tác giả), Jae Berm Park (Tác giả), Pavel Gershkovich (Tác giả), Sun Dong Yoo (Tác giả), Soyoung Shin (Tác giả), Beom Soo Shin (Tác giả), Sung Joo Kim (Tác giả)
• Định dạng: Sách
• Được phát hành: Elsevier, 2019-02-01T00:00:00Z.
• Những chủ đề: article
• Truy cập trực tuyến: Connect to this object online.

Tacrolimus is one of the most commonly used immunosuppressive agents in animal models of transplantation. However, in these models, oral administration is often problematic due to the lowered compliance associated with highly invasive surgery and due to malabsorption in the intestinal tract. Therefo...