Validation of a simple and rapid HPLC-UV method for simultaneous analysis of co-delivered doxorubicin and verapamil and its application to characterization of PLGA nanoparticles

• Glavni autori: Maryam Kazemi (Autor), Fatemeh Ahmadi (Autor), Mozhdeh Piltan (Autor), Shohre Alipour (Autor)
• Format: Knjiga
• Izdano: Shiraz University of Medical Sciences, 2022-12-01T00:00:00Z.
• Teme: article
• Online pristup: Connect to this object online.

To overcome developing drug resistance in cancer treatment, combination therapy could be an attractive strategy. It has been shown that doxorubicin anti-cancer properties are improved by P-glycoprotein inhibitors such as verapamil. Polymeric nanoparticles (NPs) of poly lactic-co-glycolic acid (PLGA)...