Elevated murine HB-EGF confers sensitivity to diphtheria toxin in EGFR-mutant lung adenocarcinoma

• Hlavní autoři: Camila Robles-Oteiza (Autor), Deborah Ayeni (Autor), Stellar Levy (Autor), Robert J. Homer (Autor), Susan M. Kaech (Autor), Katerina Politi (Autor)
• Médium: Kniha
• Vydáno: The Company of Biologists, 2021-11-01T00:00:00Z.
• Témata: article
• On-line přístup: Connect to this object online.

Conditional ablation of defined cell populations in vivo can be achieved using genetically engineered mice in which the human diphtheria toxin (DT) receptor (DTR) is placed under control of a murine tissue-specific promotor, such that delivery of DT selectively ablates cells expressing this high-aff...