Canagliflozin Ameliorates NLRP3 Inflammasome-Mediated Inflammation Through Inhibiting NF-κB Signaling and Upregulating Bif-1

• Main Authors: Yaoyun Niu (Author), Yuehui Zhang (Author), Wanqiu Zhang (Author), Jinghua Lu (Author), Yang Chen (Author), Wenhui Hao (Author), Jin Zhou (Author), Lijun Wang (Author), Weidong Xie (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

NOD-, LRR-, and pyrin domain-containing protein 3 (NLRP3) inflammasome is an important component of the innate immune system that mediates the secretion of the pro-inflammatory cytokines interleukin-1β (IL-1β) and IL-18. However, current studies have shown that the abnormal activation of the NLRP3 i...