Measurement of CYP1A2 and CYP3A4 activity by a simplified Geneva cocktail approach in a cohort of free-living individuals: a pilot study

• Asıl Yazarlar: Constance A. Sobsey (Yazar), Noor Mady (Yazar), Vincent R. Richard (Yazar), Andre LeBlanc (Yazar), Thomas Zakharov (Yazar), Christoph H. Borchers (Yazar), R. Thomas Jagoe (Yazar)
• Materyal Türü: Kitap
• Baskı/Yayın Bilgisi: Frontiers Media S.A., 2024-02-01T00:00:00Z.
• Konular: article
• Online Erişim: Connect to this object online.

Introduction: The cytochrome P450 enzyme subfamilies, including CYP3A4 and CYP1A2, have a major role in metabolism of a range of drugs including several anti-cancer treatments. Many factors including environmental exposures, diet, diseaserelated systemic inflammation and certain genetic polymorphism...