Smurf1 Facilitates Oxidative Stress and Fibrosis of Ligamentum Flavum by Promoting Nrf2 Ubiquitination and Degradation

Smurf1 Facilitates Oxidative Stress and Fibrosis of Ligamentum Flavum by Promoting Nrf2 Ubiquitination and Degradation

Lumbar spinal stenosis (LSS), which can lead to irreversible neurologic damage and functional disability, is characterized by hypertrophy and fibrosis in the ligamentum flavum (LF). However, the underlying mechanism is still unclear. In the current study, the effect of Smurf1, a kind of E3 ubiquitin...

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Main Authors: Yifei Gu (Author), Jinquan Hu (Author), Chen Wang (Author), Min Qi (Author), Yu Chen (Author), Wenchao Yu (Author), Zhanchao Wang (Author), Xinwei Wang (Author), Wen Yuan (Author)
Format: Book
Published: Hindawi Limited, 2023-01-01T00:00:00Z.
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