Structure-based drug discovery of novel fused-pyrazolone carboxamide derivatives as potent and selective AXL inhibitors

• Main Authors: Feifei Fang (Author), Yang Dai (Author), Hao Wang (Author), Yinchun Ji (Author), Xuewu Liang (Author), Xia Peng (Author), Jiyuan Li (Author), Yangrong Zhao (Author), Chunpu Li (Author), Danyi Wang (Author), Yazhou Li (Author), Dong Zhang (Author), Dan Zhang (Author), Meiyu Geng (Author), Hong Liu (Author), Jing Ai (Author), Yu Zhou (Author)
• Formato: Libro
• Publicado: Elsevier, 2023-12-01T00:00:00Z.
• Subjects: article
• Acceso en liña: Connect to this object online.

As a novel and promising antitumor target, AXL plays an important role in tumor growth, metastasis, immunosuppression and drug resistance of various malignancies, which has attracted extensive research interest in recent years. In this study, by employing the structure-based drug design and bioisost...