Concomitant Treatment with Voriconazole and Flucloxacillin: A Combination to Avoid

• Main Authors: Ruth Van Daele (Author), Joost Wauters (Author), Pieter De Cock (Author), Franky Buyle (Author), John Leys (Author), Pieter Van Brantegem (Author), Matthias Gijsen (Author), Pieter Annaert (Author), Yves Debaveye (Author), Katrien Lagrou (Author), Willy E. Peetermans (Author), Roger J. Brüggemann (Author), Isabel Spriet (Author)
• Format: Book
• Published: MDPI AG, 2021-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: Voriconazole is an antifungal drug used as one of the first-line treatments for invasive aspergillosis. This drug is extensively metabolized, predominantly via cytochrome P450 enzymes. An interaction between flucloxacillin and voriconazole, leading to subtherapeutic voriconazole concentr...