The role of local IL6/JAK2/STAT3 signaling in high glucose-induced podocyte hypertrophy

• Main Authors: Hyung Ah Jo (Author), Joo-Young Kim (Author), Seung Hee Yang (Author), Seung Seok Han (Author), Kwon Wook Joo (Author), Yon Su Kim (Author), Dong Ki Kim (Author)
• Format: Book
• Published: The Korean Society of Nephrology, 2016-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: Interleukin-6 (IL6) is an important regulator of cellular hypertrophy through the gp130/Janus kinase 2 (JAK2)/signal transducer and activator of transcription 3 (STAT3) pathway. We tested the hypothesis that IL6 and its downstream gp130/JAK2/STAT3 pathway participated in high glucose (HG...