Small interfering RNA mediated Poly (ADP-ribose) Polymerase-1 inhibition upregulates the heat shock response in a murine fibroblast cell line

Small interfering RNA mediated Poly (ADP-ribose) Polymerase-1 inhibition upregulates the heat shock response in a murine fibroblast cell line

<p>Abstract</p> <p>Poly (ADP-ribose) polymerase-1 (PARP-1) is a highly conserved multifunctional enzyme, and its catalytic activity is stimulated by DNA breaks. The activation of PARP-1 and subsequent depletion of nicotinamide adenine dinucleotide (NAD<sup>+</sup>) and...

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Main Authors: Zingarelli Basilia (Author), Gefter Julia V (Author), Sjodin Hanna (Author), Aneja Rajesh K (Author), Delude Russell L (Author)
Format: Book
Published: BMC, 2011-02-01T00:00:00Z.
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