Small interfering RNA mediated Poly (ADP-ribose) Polymerase-1 inhibition upregulates the heat shock response in a murine fibroblast cell line

• मुख्य लेखकों: Zingarelli Basilia (लेखक), Gefter Julia V (लेखक), Sjodin Hanna (लेखक), Aneja Rajesh K (लेखक), Delude Russell L (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: BMC, 2011-02-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

<p>Abstract</p> <p>Poly (ADP-ribose) polymerase-1 (PARP-1) is a highly conserved multifunctional enzyme, and its catalytic activity is stimulated by DNA breaks. The activation of PARP-1 and subsequent depletion of nicotinamide adenine dinucleotide (NAD⁺) and...