MrgX2 is a promiscuous receptor for basic peptides causing mast cell pseudo‐allergic and anaphylactoid reactions

• Main Authors: Jak Grimes (Author), Sapna Desai (Author), Neil W. Charter (Author), James Lodge (Author), Rita Moita Santos (Author), Albert Isidro‐Llobet (Author), Andrew M. Mason (Author), Zining Wu (Author), Lawrence A. Wolfe III (Author), Lakshmi Anantharaman (Author), Andrew Green (Author), Angela M. Bridges (Author), Deidre A. Dalmas Wilk (Author), Andrew J. Brown (Author)
• Format: Book
• Published: Wiley, 2019-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Activation of MrgX2, an orphan G protein‐coupled receptor expressed on mast cells, leads to degranulation and histamine release. Human MrgX2 binds promiscuously to structurally diverse peptides and small molecules that tend to have basic properties (basic secretagogues), resulting in acute...