In silico Prioritization of Transporter-Drug Relationships From Drug Sensitivity Screens

• Main Authors: Adrián César-Razquin (Author), Enrico Girardi (Author), Mi Yang (Author), Marc Brehme (Author), Julio Saez-Rodriguez (Author), Giulio Superti-Furga (Author)
• Format: Book
• Published: Frontiers Media S.A., 2018-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The interplay between drugs and cell metabolism is a key factor in determining both compound potency and toxicity. In particular, how and to what extent transmembrane transporters affect drug uptake and disposition is currently only partially understood. Most transporter proteins belong to two prote...