Pharmacokinetic Variability Drives Palbociclib-Induced Neutropenia in Metastatic Breast Cancer Patients: Drug-Drug Interactions Are the Usual Suspects

• Main Authors: Fanny Leenhardt (Author), Frédéric Fiteni (Author), Ludovic Gauthier (Author), Marie Alexandre (Author), Séverine Guiu (Author), Nelly Firmin (Author), Stéphane Pouderoux (Author), Marie Viala (Author), Gerald Lossaint (Author), Chloé Gautier (Author), Caroline Mollevi (Author), Matthieu Gracia (Author), Celine Gongora (Author), Litaty Mbatchi (Author), Alexandre Evrard (Author), William Jacot (Author)
• Format: Book
• Published: MDPI AG, 2022-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Palbociclib is a good candidate for therapeutic drug monitoring (TDM) due to its narrow therapeutic range and frequency of toxicities, particularly high-grade neutropenia. In this prospective, bicentric clinical trial, we evaluated the palbociclib exposure-toxicity relationship and determined the re...