Extracellular acidification-induced CXCL8 production through a proton-sensing receptor OGR1 in human airway smooth muscle cells: a response inhibited by dexamethasone

• Main Authors: Maiko Kadowaki (Author), Hidenori Yamada (Author), Koichi Sato (Author), Hiroko Shigemi (Author), Yukihiro Umeda (Author), Miwa Morikawa (Author), Yuko Waseda (Author), Masaki Anzai (Author), Yosuke Kamide (Author), Haruka Aoki-Saito (Author), Takeshi Hisada (Author), Fumikazu Okajima (Author), Tamotsu Ishizuka (Author)
• Format: Book
• Published: BMC, 2019-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Human airway smooth muscle cells (ASMCs) contribute to bronchial contraction and airway hyperresponsiveness in patients with bronchial asthma. They also generate cytokines, chemokines, and matricellular proteins. Ovarian cancer G protein-coupled receptor 1 (OGR1) senses extracell...