Physiologically‐based pharmacokinetic modeling of remdesivir and its metabolites in pregnant women with COVID‐19

• Главные авторы: Xiaomei I. Liu (Автор), André Dallmann (Автор), Kristina Brooks (Автор), Brookie M. Best (Автор), Diana F. Clarke (Автор), Mark Mirochnick (Автор), John N. van denAnker (Автор), Edmund V. Capparelli (Автор), Jeremiah D. Momper (Автор)
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• Опубликовано: Wiley, 2023-02-01T00:00:00Z.
• Предметы: article
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Abstract Pregnant individuals are at high risk for severe illness from COVID‐19, and there is an urgent need to identify safe and effective therapeutics for this population. Remdesivir (RDV) is a SARS‐CoV‐2 nucleotide analog RNA polymerase inhibitor. Limited RDV pharmacokinetic (PK) and safety data...