Identification of NAPRT Inhibitors with Anti-Cancer Properties by In Silico Drug Discovery

• Главные авторы: Moustafa S. Ghanem (Автор), Irene Caffa (Автор), Alberto Del Rio (Автор), Jorge Franco (Автор), Marco Daniele Parenti (Автор), Fiammetta Monacelli (Автор), Michele Cea (Автор), Amr Khalifa (Автор), Aimable Nahimana (Автор), Michel A. Duchosal (Автор), Silvia Ravera (Автор), Nadia Bertola (Автор), Santina Bruzzone (Автор), Alessio Nencioni (Автор), Francesco Piacente (Автор)
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• Опубликовано: MDPI AG, 2022-07-01T00:00:00Z.
• Предметы: article
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Depriving cancer cells of sufficient NAD levels, mainly through interfering with their NAD-producing capacity, has been conceived as a promising anti-cancer strategy. Numerous inhibitors of the NAD-producing enzyme, nicotinamide phosphoribosyltransferase (NAMPT), have been developed over the past tw...