Deregulation of the spindle assembly checkpoint is associated with paclitaxel resistance in ovarian cancer

• Main Authors: Taryne Chong (Author), Amila Sarac (Author), Cindy Q. Yao (Author), Linda Liao (Author), Nicola Lyttle (Author), Paul C. Boutros (Author), John M. S. Bartlett (Author), Melanie Spears (Author)
• Format: Book
• Published: BMC, 2018-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Ovarian cancer is the leading gynecologic cancer diagnosed in North America and because related symptoms are not disease specific, this often leads to late detection, an advanced disease state, and the need for chemotherapy. Ovarian cancer is frequently sensitive to chemotherapy...