Dosing Optimization of Posaconazole in Lung-Transplant Recipients Based on Population Pharmacokinetic Model

• Main Authors: Eliška Dvořáčková (Author), Martin Šíma (Author), Andrea Zajacová (Author), Kristýna Vyskočilová (Author), Tereza Kotowski (Author), Kateřina Dunovská (Author), Eva Klapková (Author), Jan Havlín (Author), Robert Lischke (Author), Ondřej Slanař (Author)
• Format: Book
• Published: MDPI AG, 2023-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Although posaconazole tablets show relatively low variability in pharmacokinetics (PK), the proportion of patients achieving the PK/PD target at the approved uniform dose for both prophylaxis and therapy is not satisfactory. The aim of this study was to develop a posaconazole population PK model in...