Dosing Optimization of Posaconazole in Lung-Transplant Recipients Based on Population Pharmacokinetic Model

• Główni autorzy: Eliška Dvořáčková (Autor), Martin Šíma (Autor), Andrea Zajacová (Autor), Kristýna Vyskočilová (Autor), Tereza Kotowski (Autor), Kateřina Dunovská (Autor), Eva Klapková (Autor), Jan Havlín (Autor), Robert Lischke (Autor), Ondřej Slanař (Autor)
• Format: Książka
• Wydane: MDPI AG, 2023-09-01T00:00:00Z.
• Hasła przedmiotowe: article
• Dostęp online: Connect to this object online.

Although posaconazole tablets show relatively low variability in pharmacokinetics (PK), the proportion of patients achieving the PK/PD target at the approved uniform dose for both prophylaxis and therapy is not satisfactory. The aim of this study was to develop a posaconazole population PK model in...