Glomerular Damage in Trichloroethylene-Sensitized Mice: Targeting Cathepsin L-Induced Hyperactive mTOR Signaling

• Main Authors: Feng Wang (Author), Yuying Dai (Author), Meng Huang (Author), Chenchen Zhang (Author), Liping Huang (Author), Hui Wang (Author), Liangping Ye (Author), Qifeng Wu (Author), Xuejun Zhang (Author), Qixing Zhu (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Trichloroethylene (TCE) is a serious health hazard for workers with daily exposure, causing occupational medicamentosa-like dermatitis due to TCE (OMDT) and glomerular damage. Recent studies suggest that mTORC1 signaling is activated in various glomerular disorders; however, the role of mTORC1 signa...