P2Y Receptor-Mediated Ca2+ Signaling Increases Human Vascular Endothelial Cell Permeability

• Main Authors: Naoko Tanaka (Author), Kumiko Kawasaki (Author), Namie Nejime (Author), Yoko Kubota (Author), Kazuki Nakamura (Author), Masaru Kunitomo (Author), Koichi Takahashi (Author), Michio Hashimoto (Author), Kazumasa Shinozuka (Author)
• Format: Book
• Published: Elsevier, 2004-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

We investigated the effects of P2-receptor agonists on cell size, intracellular calcium levels ([Ca2+]i), and permeation of FITC-labeled dextran (FD-4) as well as the relationship between these effects in human umbilical vein endothelial cells (HUVEC). FD-4 concentration, cell size, and [Ca2+]i were...