Pharmacokinetics and safety of highly variable valsartan in single-pill combination with amlodipine versus its generic formulation: a randomized, three-cycle, three-sequence, partially replicated crossover phase I bioequivalence clinical trial

Valsartan/amlodipine (I) is a single-pill combination (SPC) of an angiotensin II receptor blocker (ARB) and a calcium channel blocker (CCB) for treating hypertension. A clinical trial was performed to demonstrate that the test and reference valsartan/amlodipine formulations were bioequivalent under...

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Main Authors: Bo Qiu (Author), Haojing Song (Author), Congyang Ding (Author), Xue Sun (Author), Runxuan Du (Author), Haotian Yang (Author), Wanjun Bai (Author), Zhanjun Dong (Author)
Format: Book
Published: Frontiers Media S.A., 2023-09-01T00:00:00Z.
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