L-cysteine ethyl ester prevents and reverses acquired physical dependence on morphine in male Sprague Dawley rats

• Main Authors: James N. Bates (Author), Paulina M. Getsy (Author), Gregory A. Coffee (Author), Santhosh M. Baby (Author), Peter M. MacFarlane (Author), Yee-Hsee Hsieh (Author), Zackery T. Knauss (Author), Jason A. Bubier (Author), Devin Mueller (Author), Stephen J. Lewis (Author)
• Format: Book
• Published: Frontiers Media S.A., 2023-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The molecular mechanisms underlying the acquisition of addiction/dependence on morphine may result from the ability of the opioid to diminish the transport of L-cysteine into neurons via inhibition of excitatory amino acid transporter 3 (EAA3). The objective of this study was to determine whether th...