L-cysteine ethyl ester prevents and reverses acquired physical dependence on morphine in male Sprague Dawley rats

• Autori principali: James N. Bates (Autore), Paulina M. Getsy (Autore), Gregory A. Coffee (Autore), Santhosh M. Baby (Autore), Peter M. MacFarlane (Autore), Yee-Hsee Hsieh (Autore), Zackery T. Knauss (Autore), Jason A. Bubier (Autore), Devin Mueller (Autore), Stephen J. Lewis (Autore)
• Natura: Libro
• Pubblicazione: Frontiers Media S.A., 2023-12-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

The molecular mechanisms underlying the acquisition of addiction/dependence on morphine may result from the ability of the opioid to diminish the transport of L-cysteine into neurons via inhibition of excitatory amino acid transporter 3 (EAA3). The objective of this study was to determine whether th...